analysis blind spot dataset
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blind spot dataset

Tour de Force Proteomics Dataset Reveals New Clues to Small Molecule Mechanism of Action (MOA) and Off-Target Effects

A new study used proteomics to decipher the mechanisms of action of 875 drugs, providing a valuable resource for understanding how drugs work and developing more targeted and effective therapies.

October 17th, 2023
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2D chemical structures of six poly(ADP-ribose) polymerase (PARP) inhibitors used in this study. Top row include three FDA approved compounds (olaparib, rucaparib, and talazoparib), bottom row include
analysis blind spot

Cancer Microbiome Reanalysis

A bioXriv preprint contends that a 2020 paper linking bacteria to cancer was based on flawed data analyses.

August 28th, 2023
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Colorized scanning electron micrograph of Group A Streptococcus (Streptococcus pyogenes) bacteria (yellow) and a human neutrophil (blue). Credit: NIAID
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